In Vivo PET Imaging of Histone Deacetylases by18F-Suberoylanilide Hydroxamic Acid (18F-SAHA)

Histone Deacetylation Inhibition in Pulmonary Hypertension: Therapeutic Potential of Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA)

Ad Ad Add dr dres ess s f fo for r C C Corresp pond dence: Abstract Background-Epigenetic programming, dynamically regulated by histone acetylation, is a key

Pharmacological Inhibition of Histone Deacetylases (HDACs) by Suberoylanilide Hydroxamic Acid (SAHA) Specifically Alters Gene Expression and Reduces Ischemic Injury in the Mouse Brain

Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells.

Mantle cell lymphoma (MCL) has a chromosomal translocation resulting in the expression of the cyclin D1 gene driven by the powerful enhancer of the immunoglobulin heavy chain gene, leading to uncontrolled, overexpressed cyclin D1 protein. We showed that suberoylanilide hydroxamic acid (SAHA; vorinostat), one of the histone deacetylase inhibitors derived from hydroxamic acid, caused a dramatic d...

P-117: Gene Expression and Developmental State of Mouse Cloned Embryos after Treatment with Histone Deacetylase Inhibitor,Suberoylanilide Hydroxamic Acid (SAHA)

Background: It is known that acetylation level of the nuclear histones in cloned embryos is lower compare to normally developed embryos. Histone deacetylas inhibitors (HDACi) with improvement of acetylation level in these embryos can affect embryo quality in pre-implantation stage and expression level of different genes especially developmental genes. Materials and Methods: In this research, SA...

In vivo imaging of cellular proliferation in renal cell carcinoma using 18F-fluorothymidine PET

Objective(s): The ability to measure cellular proliferation non-invasively in renal cell carcinoma may allow prediction of tumour aggressiveness and response to therapy. The aim of this study was to evaluate the uptake of 18Ffluorothymidine (FLT) PET in renal cell carcinoma (RCC), and to compare this to 18F-fluorodeoxyglucose (FDG), and to an immunohistochemical measure of cellular proliferatio...